| REVIEW |
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| Year : 2018 | Volume
: 1
| Issue : 1 | Page : 2-8 |
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Myeloid-derived suppressor cells and nonresolving inflammatory cells in glioma microenvironment: molecular mechanisms and therapeutic strategies
Xiao-Yan Ji1, Jia-Wei Ma2, Jun Dong1
1 Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
2 Department of Critical Care Medicine, Wuxi No.2 Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
Correspondence Address:
Dr. Jia-Wei Ma
Department of Critical Care Medicine, Wuxi No.2 Hospital, Nanjing Medical University, Nanjing 214002, Jiangsu
China
Prof. Jun Dong
Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, Jiangsu
China
 Source of Support: None, Conflict of Interest: None  | 4 |
DOI: 10.4103/glioma.glioma_2_17
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Myeloid-derived suppressor cells (MDSCs) are a subgroup of immunosuppressive heterogeneous cells derived from bone marrow (BM) stem cells. They not only strongly inhibit T cell-mediated antitumor immune response but also directly induce tumorigenesis and promote tumor growth and metastasis. Besides, the nonresolving inflammation (NRI), a prime cause of tumor development, is present in the glioma microenvironment. However, the relationship between MDSCs and NRI, especially in the view of relevant molecular regulatory networks, has not been fully elucidated in gliomas. In the present study, the MDSC- and NRI-associated molecular regulatory network and key regulatory points are reviewed, and the targeted therapeutic strategies against gliomas are further discussed.
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