• Users Online: 185
  • Print this page
  • Email this page
REVIEW
Year : 2018  |  Volume : 1  |  Issue : 2  |  Page : 43-49

Angiogenesis in glioma


Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China

Correspondence Address:
Dr. Xue-Jun Li
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/glioma.glioma_9_18

Rights and Permissions

Despite aggressive surgery, radiotherapy, and chemotherapy, malignant gliomas remain uniformly fatal. To progress, these tumors stimulate the formation of new blood vessels through processes driven primarily by angiogenesis factors. However, the resulting vessels are structurally and functionally abnormal and contribute to a hostile microenvironment that is highly selective for a more malignant phenotype with increased morbidity and mortality. Emerging preclinical and clinical data indicate that antiangiogenesis therapies are potentially effective regarding glioblastoma, and can transiently normalize tumor vessels. This creates a window of opportunity for optimally combining chemotherapeutics and radiation.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4035    
    Printed273    
    Emailed1    
    PDF Downloaded434    
    Comments [Add]    
    Cited by others 1    

Recommend this journal