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Year : 2018  |  Volume : 1  |  Issue : 6  |  Page : 189-195

Intraoperative fluorescence-guided resection of high-grade glioma: A systematic review

1 Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China
2 Department of Preventive Medicine, West-China School of Public Health, Sichuan University, Chengdu, Sichuan, China
3 Department of Neurosurgery, Bishan Hospital, Chongqing Medical University, Chongqing, China

Correspondence Address:
Dr. Sheng-Qing Lv
Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/glioma.glioma_41_18

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High-grade glioma (HGG) is a devastating disease with very poor prognosis. Maximal resection of HGG improves survival and maximal visualization of the tumor, if reliable, improves the resection. Fluorescence is widely used as guidance mechanism and has demonstrated potential in maximizing the extent of HGG resection. Our goal is to summarize the current techniques using fluorescence during the resection of HGG and demonstrate how its use increases gross total resection rates, overall survival (OS), and progression-free survival (PFS). However, further prospective, multicenter, randomized controlled trials are still in need to prove the advantage of fluorescence-guided surgery on patients' OS/PFS.

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