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REVIEW
Year : 2022  |  Volume : 5  |  Issue : 1  |  Page : 12-19

Glioma stem cells and their microenvironment: A narrative review on docking and transformation


1 Department of Neurosurgery, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China
2 Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
3 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4 Department of Neurosurgery and Brain Tumor Research Laboratory, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China

Correspondence Address:
Dr. Yaodong Zhao
No. 650 New Songjiang Road, Songjiang District, Shanghai 201600; Prof. Qiang Huang, No. 1055 Sanxiang Road, Gusu District, Suzhou 215004, Jiangsu Province
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/glioma.glioma_5_22

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Significant new progress was made 10 years ago in the hypothesis that neuroglial cells, neural stem cells, and glioma stem cells (GSCs) depend on the tumor microenvironment (TME) transformation: (1) Because GSCs also have heterogeneity, they are a state, not an entity. (2) The importance of the border niche among many tumor niches is emphasized because it is a shelter for tumor resistance to radiotherapy and chemotherapy. (3) The plasticity of GSCs and TME cells allows TME cells to become GSC-initiating cells. (4) Future development will entail a close interaction between high-throughput molecular biology and artificial intelligence. In this review, we summarize recent advances in GSCs and their microenvironment from the following three aspects: the constantly updated of concept of stem cells, the concept of TME and niche, and the plasticity of GSCs and TME cells.


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