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  Indian J Med Microbiol
 

Figure 4: Schematic view of molecular testing of isocitrate dehydrogenase-wildtype midline glioma. H3-K27M-mutation and isocitrate dehydrogenase-1 mutations are mutually exclusive. Midline tumors, which are isocitrate dehydrogenase wildtype, should be tested for H3-K27M-mutation status. H3-K27M wildtype has a better prognosis compared to the mutated form. Cases positive for the H3-K27M mutation should have histone H3 gene sequencing. Alpha thalassemia/mental retardation syndrome X-linked

Figure 4: Schematic view of molecular testing of isocitrate dehydrogenase-wildtype midline glioma. <i>H3-K27M</i>-mutation and isocitrate dehydrogenase-1 mutations are mutually exclusive. Midline tumors, which are isocitrate dehydrogenase wildtype, should be tested for <i>H3-K27M</i>-mutation status. <i>H3-K27M</i> wildtype has a better prognosis compared to the mutated form. Cases positive for the <i>H3-K27M</i> mutation should have histone H3 gene sequencing. Alpha thalassemia/mental retardation syndrome X-linked