Figure 2: Relationship between collagens and their receptors and gliomas. Collagens and their receptors modulate glioma proliferation, invasion, and migration by activating various collagen receptors. MMPs work with collagen receptors to modulate collagen remodeling and increase the invasion ability of glioma cells. DDR: Discoidin domain receptor, ECM: Extracellular matrix, FAK: Focal adhesion kinase, MMP: Matrix metalloproteinase