Figure 1: Methylation-based T-SNE analysis including six selected cases with reference cases. Case 1 and Case 3 exhibit typical diagnostic-relevant chromosome changes in accordance with their methylation group refers. Case 2 detected a 1p/19q co-del by FISH. Case 4, 5, and 6 are tumors that exhibit glioblastoma-like 7+/10-chromosome changes but belong to ganglioglioma and PXA. AIDH: Astrocytoma, IDH-mutant, GBM_MYCN: Diffuse pediatric-type high-grade glioma MYCN subtype, GBM_RTKI: Glioblastoma, IDH-wildtype, RTKI methylation subtype, GBM_RTKII: Glioblastoma, IDH-wildtype, RTKII methylation subtype, HGAP: High-grade astrocytoma with piloid features, LGG_GG: Ganglioglioma, OIDH: Oligodendroglioma, IDH-mutant and 1p/19q-codeleted, PXA: Pleomorphic xanthoastrocytoma. Original source of Figure 1 was selected from GEO reference dataset (GSE109381).[23] The raw data were selected and reanalyzed via R package "Rtsne" using 20000 most variable CpG sites
![Figure 1: Methylation-based T-SNE analysis including six selected cases with reference cases. Case 1 and Case 3 exhibit typical diagnostic-relevant chromosome changes in accordance with their methylation group refers. Case 2 detected a 1p/19q co-del by FISH. Case 4, 5, and 6 are tumors that exhibit glioblastoma-like 7+/10-chromosome changes but belong to ganglioglioma and PXA. AIDH: Astrocytoma, IDH-mutant, GBM_MYCN: Diffuse pediatric-type high-grade glioma MYCN subtype, GBM_RTKI: Glioblastoma, IDH-wildtype, RTKI methylation subtype, GBM_RTKII: Glioblastoma, IDH-wildtype, RTKII methylation subtype, HGAP: High-grade astrocytoma with piloid features, LGG_GG: Ganglioglioma, OIDH: Oligodendroglioma, IDH-mutant and 1p/19q-codeleted, PXA: Pleomorphic xanthoastrocytoma. Original source of Figure 1 was selected from GEO reference dataset (GSE109381).<sup>[23]</sup> The raw data were selected and reanalyzed via R package "Rtsne" using 20000 most variable CpG sites](articles/2022/5/4/images/Glioma_2022_5_4_120_371294_f1.jpg)